Protein Details: ATP-sensitive inward rectifier potassium channel 11

Protein ID

ICDB_Pro_0833

Protein Name

ATP-sensitive inward rectifier potassium channel 11

Gene Name

KCNJ11

Organism

Homo sapiens (Human)

Length

390 amino acids

AlphaFoldDB

AF-Q14654-F1-model_v4.pdb

Function

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation

Sequence

MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS

PDB Structures

6C3O 6C3P 7S5T 7S5X 7S5Y 7S5Z 7S60 7S61

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Hyperinsulinemic Hypoglycemia;Familial;and Diabetes Mellitus;Transient Neonatal

Location

DOI ID

10.1126/science.270.5239.1166; 10.1038/ng1285; 10.1038/nature04632; 10.1101/gr.2596504; 10.1161/01.res.83.11.1132; 10.1016/s0006-3495(03)74847-4; 10.1212/01.wnl.0000268488.51776.53; 10.1172/jci35414; 10.1093/hmg/ddp179; 10.1093/hmg/ddp554; 10.1002/(sici)1098-1004(1999)13:5<351::aid-humu3>3.0.co;2-r; 10.1113/jphysiol.2007.143149; 10.1016/j.neuroscience.2008.01.003; 10.1371/journal.pone.0037423; 10.1074/jbc.m117.804971; 10.1093/hmg/5.11.1809; 10.1007/bf02658512; 10.2337/diab.46.3.502; 10.1210/edrv.20.2.0361; 10.1038/10297; 10.1210/jc.2002-020378; 10.2337/diabetes.53.10.2713; 10.2337/diabetes.53.10.2719; 10.1210/jc.2004-0568; 10.1210/jc.2004-1233; 10.1056/nejmoa032922; 10.1073/pnas.0404756101; 10.1111/j.1365-2265.2005.02242.x; 10.1093/hmg/ddi086; 10.1002/humu.20124; 10.1210/jc.2004-1604; 10.1210/jc.2005-0096; 10.1210/jc.2005-0202; 10.2337/db05-1640; 10.1007/s00125-006-0246-z; 10.1002/humu.9401; 10.1074/jbc.m511875200; 10.1038/modpathol.3800497; 10.1210/jc.2006-2490

RefSeq

NP_000516.3 [Q14654-1]; NP_001159762.1 [Q14654-2]